nucleotidases การใช้

• ENTPD6 is similar to E-type nucleotidases ( NTPases ).
• Studies of mammalian 5'nucleotidases have shown that there exist at least four different forms of the 5'nucleotidase enzyme : one membrane-bound form and three soluble forms.
• Nucleosides can be produced by de novo synthesis pathways, in particular in the liver, but they are more abundantly supplied via ingestion and digestion of nucleic acids in the diet, whereby nucleotidases break down " nucleotides " ( such as the thymidine monophosphate ) into " nucleosides " ( such as thymidine ) and phosphate.
• AMP as its substrate . cN-II is identified by its affinity toward either IMP or GMP or both . cN-III is a pyrimidine 5'- nucleotidase . 5'- Nucleotidases are involved in varied functions like cell cell communication, nucleic acid repair, purine salvage pathway for the synthesis of nucleotides, signal transduction, membrane transport, etc.
• CdN is one of seven 5'nucleotidases identified in humans, all of which differ in tissue specificity, subcellular location, primary structure and mdN, is the most closely related to cdN . Their genes, " NT5M " and " NT5C ", share the same exon / intron organization, and their amino acid sequences are 52 % identical.
• MdN is one of seven 5'nucleotidases identified in humans, all of which differ in tissue specificity, subcellular location, primary structure and cdN, is the most closely related to mdN . Their genes, " NT5M " and " NT5C ", share the same exon / intron organization, and their amino acid sequences are 52 % identical.