organification การใช้

• Thiocyanate inhibits thyroid iodide transport and, at high doses, competes with iodide in the organification process within thyroid tissue.
• A radioactive iodine ( RAIU ) exam will help differentiate congenital absence or a defect in organification ( a process necessary to make thyroid hormone ).
• Six mg of iodide a day can be used to treat patients with hyperthyroidism due to its ability to inhibit the organification process in thyroid hormone synthesis, the so-called Wolff-Chaikoff Effect.
• Positron emission tomography data show that with KCNE2, 124I uptake by the thyroid is impaired . " Kcne2 " deletion does not impair organification of iodide once it has been taken up by NIS . Pups raised by " Kcne2 "-/-dams are particularly severely affected because rhey receive less milk ( hypothyroidism of the dams impairs milk ejection ), the milk they receive is deficient in T 4, and they themselves cannot adequately transport iodide into the thyroid . " Kcne2 "-/-pups exhibit stunted growth, alopecia, cardiomegaly and reduced cardiac ejection fraction, all of which are alleviated by thyroid hormone supplementation of pups or dams.