orphenadrine การใช้

• Orphenadrine Blanex, Disipal, Noradex, O-Flex, Orfro
• She was then administered orphenadrine, which soon stopped the patient s tilting posture.
• For example, antihistamines including orphenadrine combat the release of histamine caused by many opioids.
• Foremost amongst these are nefopam, orphenadrine, and perhaps phenyltoloxamine or some other antihistamines.
• The generic is a combination of 385 mg of aspirin and 25 mg of orphenadrine citrate.
• Within a couple of days of exhibiting symptoms, the patient was then treated with orphenadrine.
• It may also interact with anticholinergic drugs such as orphenadrine to produce hypoglycaemia ( low blood sugar ).
• The patient was then switched to a small dosage of haloperidol along with the typical dosage of orphenadrine used on the previous patients.
• Orphenadrine and other muscle relaxants are sometimes used to treat pain arising from rheumatoid arthritis but there is no evidence they are effective for that purpose.
• Prior to the development of amantadine in the late 1960s and then other drugs, anticholinergics like orphenadrine were the mainstay of Parkinson's treatment.
• The closely related drugs atropine and scopolamine and other members of the anticholinergic drug group like cyclobenzaprine, trihexyphenidyl, and orphenadrine are also used for this purpose.
• Kornhuber described novel molecular mechanisms of approved psychotropic drugs, namely that memantine, amantadine, budipine and orphenadrine act as low-affinity NMDA-receptor antagonists.
• Orphenadrine and other anticholinergics have largely been superseded by other drugs; they have a use in alleviating motor function symptoms, and appear to help about 20 % of people with Parkinson's.
• Recently, like its analogue orphenadrine which also has analgesic effects, nefopam has been found to act as a voltage-gated sodium channel blocker, and this may in part or fully mediate its antinociceptive effects.
• In this respect, it is similar to a closely related antihistamine, orphenadrine, and both drugs are very closely related to diphenhydramine and to doxylamine, the latter of which is the active ingredient in NyQuil and many other cough preparations.
• Adjuvant analgesics, also called atypical analgesics, include nefopam, orphenadrine, pregabalin, gabapentin, cyclobenzaprine, scopolamine, and other drugs possessing anticonvulsant, anticholinergic, and / or antispasmodic properties, as well as many other drugs with CNS actions.
• Cyclobenzaprine has been found to be not inferior to tizanidine, orphenadrine, and carisoprodol in the treatment of acute lower back pain, although none has been proven to be effective for long-term use ( beyond two weeks of treatment ).
• Diarrhoea accompanied by significant cramping or intestinal cramping alone may benefit from either adding another smooth-muscle agent to the protocol such as dicycloverine, papaverine, or orphenadrine ( which accomplishes several things at once since it is an antihistamine as noted above ).
• This does not deter the use of single doses of difenoxin to potentiate another opiate, the anticholingeric activity of a single tablet is actually likely to increase the pleasurable effects of opioid use in a manner similar to combining one or more opioids with orphenadrine.
• A 2003 Cochrane Review of the use of anticholinergic drugs to improve motor function in Parkinson's disease found that as a class, the drugs are useful for that purpose; it identified one single-site randomised, cross-over study of orphenadrine vs placebo.