ototoxic การใช้

• Those damages can occur even at doses that are not considered ototoxic.
• Macrolide antibiotics, including erythromycin, are associated with reversible ototoxic effects.
• Drug exposures mixed with noise potentially lead to increased risk of ototoxic hearing loss.
• Several other skin preparations have been shown to be potentially ototoxic in the animal model.
• Noise exposure combined with the chemotherapeutic cisplatin puts individuals at increased risk of ototoxic hearing loss.
• Hazards to the hearing of workers include industrial noise, and exposure to various ototoxic chemicals.
• Opiates in combination with excessive noise levels may also have an additive affect on ototoxic hearing loss.
• Several medicines have ototoxic effects, and can have a cumulative effect that can increase the damage done by noise.
• These acute ototoxic side effects inhibit ion transport resulting in accumulation of ions in the extracellular space leading to edema.
• A rare mitochondrial mutation, m . 1555A > G, can increase an individual's susceptibility to the ototoxic effect of aminoglycosides.
• Contact with "'ototoxic chemicals "'such as styrene, toluene and carbon disulfide heighten the risk of auditory damages.
• Damage to the cochlea can occur in several ways, for example by viral infection, exposure to ototoxic chemicals, and intense noise exposure.
• Topical skin preparations such as chlorhexidine and ethyl alcohol have the potential to be ototoxic should they enter the inner ear through the round window membrane.
• The American Academy of Audiology recommends people being treated with ototoxic chemotherapeutics avoid excessive noise levels during treatment and for several months following cessation of treatment.
• Mitochondrial mutations can cause SNHL i . e . m . 1555A > G which makes the individual sensitive to the ototoxic effects of aminoglycoside antibiotics.
• If ototoxic medications must be administered, close attention by the physician to prescription details, such as dose and dosage interval, can reduce the damage done.
• In some cases, the loss is extremely sudden and can be traced to specific diseases, such as meningitis, or to ototoxic medications, such as Gentamicin.
• Some environmental factors, such as ototoxic medication and noise exposure, appear to be more detrimental to high frequency sensitivity than to that of mid or low frequencies.
• Ototoxic drugs ( such as aspirin ) can also cause subjective tinnitus, as they may cause hearing loss, or increase the damage done by exposure to loud noise.
• Specifically, the active amplification function of the outer hair cells is very sensitive to damage from exposure to trauma from overly-loud sounds or to certain ototoxic drugs.