oxaloacetate การใช้

• It is an important anaplerotic reaction that creates oxaloacetate from pyruvate.
• Oxaloacetate will be catalysed by PEPC-K to generate phosphoenolpyruvate.
• For example, oxaloacetate is formed by malate dehydrogenase within the mitochondrion.
• Oxaloacetate is the first substrate to bind to the enzyme.
• It is involved in the production of oxaloacetate from pyruvate.
• For example, glutamate can generate oxaloacetate in 2 steps.
• Finally, phosphoenolpyruvate carboxykinase ( PEPCK ) converts oxaloacetate to phosphoenolpyruvate ( PEP ).
• Similar to pyruvate carboxylase, PEP carboxylase replenishes oxaloacetate in the citric acid cycle.
• Once in the cytosol, aspartate is converted by cytosolic aspartate aminotransferase to oxaloacetate.
• PPDK converts pyruvate to PEP, which reacts with CO 2 to produce oxaloacetate.
• The FAHD1 protein has been shown to function as an oxaloacetate decarboxylase in eukaryotes.
• The amino group is transferred to oxaloacetate.
• GOT2 converts oxaloacetate into aspartate by transamination.
• Secondly, 2-oxoglutarate can enter tricarboxyl acid cycle in order to generate oxaloacetate.
• The pyrimidines are partly assembled from aspartate ( derived from " oxaloacetate " ).
• It is semi-essential in humans, meaning the body can synthesize it from oxaloacetate.
• This transfer is so that the oxaloacetate can be converted to aspartate or other amino acids.
• Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase.
• Oxaloacetate produced by PC is an important intermediate, which is used in these biosynthetic pathways.
• The systematic name of this enzyme class is "'oxaloacetate acetylhydrolase " '.