p70s6k การใช้

• However, several recent studies suggest that the activity of p70S6K plays a more positive role in the increase of autophagy.
• Physical exercise activates protein synthesis via phosphorylation ( activation ) of p70S6K in a pathway that is dependent on mTOR, specifically mTORC1.
• The phosphorylation of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations.
• A recent study has found that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR / p70S6K pathway in esophageal squamous cell carcinoma.
• Consistent with data observed in vitro, mTOR activity and activated p70S6K have been shown to be significantly increased in the cortex and hippocampus of animal models of AD compared to controls.
• Exercise has been shown to increase levels of IGF-1 in muscle, thus inducing the IGF-1 / PI3K / Akt / p70S6K signaling pathway, and thereby increasing the protein synthesis required to build muscle.
• T-cadherin expression increases in HUVEC under conditions of oxidative stress, and production of reactive oxygen species ( ROS ) contributes to " -cadherin elevated expression . " -cadherin overexpression in HUVEC leads to higher phosphorylation of Phosphatidylinositol 3-kinase ( PIK3 )  target of Akt, and mTOR  target p70S6K ( survival pathway regulator ), resulting in reduced levels of caspase activation and increased survival after exposure to oxidative stress.