pdgfb การใช้

• The phenotype of knock out mice demonstrates that pdgfrb is essential for vascular development, and that pdgfb is responsible for activating PDGFR? during embryogenesis.
• Pericyte-deficient mouse models ( which lack genes encoding steps in the PDGFB : PDGFRB signalling cascade ) and have an Alzheimer's-causing mutation have exacerbated Alzheimer's-like pathology compared to mice with normal pericyte coverage and an Alzheimer's-causing mutation.