perineural การใช้

• Burning dysesthesia might accurately reflect an perineural space.
• MRI provides superior soft tissue delineation such as perineural invasion when compared to CT only.
• Buckling of the bilateral optic nerves with increased perineural fluid is also often noted on MRI imaging.
• In primary neurorrhapy, with or without an interposition graft, perineural fibrosis is a common complication.
• They concluded that the latter more frequently demonstrated adverse histologic features such as lymphatic invasion, venous invasion and perineural invasion.
• Additionally, there are some cases where joint pain can respond better to perineural blocking rather than blocking of the joint.
• Tarlov perineural cysts have occasionally been observed in patients with Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome.
• Cancers can also enhance growth with nerve growth factor, possibly linked to perineural involvement where the tumor actually invades a nerve-this is associated with pancreatic cancer.
• Despite the name, the condition was first correctly described by a chiropodist named Durlacher, and although it is labeled a " neuroma ", many sources do not consider it a true tumor, but rather a perineural fibroma ( fibrous tissue formation around nerve tissue ).
• The "'olfactory transfer "'of drugs into the brain is thought to occur by either slow transport inside the olfactory nerve cells to the olfactory bulb or by faster transfer along the perineural space surrounding the olfactory nerve cells into the cerebrospinal fluid surrounding the olfactory bulbs and the brain ( 8, 9)
• Experiments done on nuclear factor ?B ( NF?B ) nuclear translocation in human perineural invasion ( PNI ) revealed that an up-regulation of NF?B and its downstream target, PIM-2, were components of an antiapoptosis signaling cascade, which is associated with cancer cells in PNI . This cascade may regulate the inhibition of apoptosis . The study also showed that elevated levels of PIM2 have been associated with PNI . The PIM2 kinase has therefore emerged as a key drug target to restore apoptosis in drug resistant human cancers.