persister การใช้

• A persister subpopulation has also been demonstrated in budding yeast " Saccharomyces cerevisiae ".
• This resistance to antibiotics in both stationary-phase cells and biofilms may be due to the presence of persister cells.
• Persister cells in " E . coli " can transport intracellular accumulations antibiotic using an energy requiring efflux pump called TolC.
• The Marshall Protocol targets the Th1 pathogens, in part, through the use of pulsed low doses of antibiotics, because they limit the growth of  persister cells . 
• Unlike persister cells, endospores are the result of a morphological differentiation process triggered by nutrient limitation ( starvation ) in the environment; endosporulation is initiated by quorum sensing within the " starving " population.
• For example, cancer cells, develop drug resistance, exhibit traits of the persister phenotype ( an extremely slow-growing physiological state which makes them insensitive to drug treatment ) and quorum sensing ( a system of stimulus and response correlated to population density ), and display many other collective behaviour capabilities and cooperative strategies necessary for survival under extreme stress.