polyploid cell การใช้

• Polyploid cells have a chromosome number that is more than twice the haploid number.
• Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate polyploid cells.
• Polyploid cells are also at the heart of experiments to determine how some cells may survive chemotherapy.
• There are also multiple reports of amitosis occurring when nuclei bud out through the plasma membrane of a polyploid cell.
• Additional examples of non-mitotic proliferation, and important insights into underlying mechanisms, have resulted from extensive work with polyploid cells.
• Diploid and polyploid cells whose chromosomes have the same allele of a given gene at some locus are called heterozygous with respect to that gene.
• A couple of decades of research has shown that polyploid cells are frequently " reduced " to diploid cells by amitosis ( Zybina et al . ).
• True polyploidy rarely occurs in humans, although polyploid cells occur in highly differentiated tissue, such as liver parenchyma and heart muscle, and in bone marrow.
• Erenpreisa and colleagues have shown that following treatment of cultured cells with mitosis-inhibiting chemicals ( similar to what is used in some chemotherapy ), a small population of induced polyploid cells survives.
• Counterintuitively, inhibition of Aurora B kinase by BI 811283 actually causes the polyploid cells formed to continue dividing however, because these cells have severe chromosomal abnormalities, they eventually stop dividing or undergo cell death.