polyribosomes การใช้

• FMRP is an RNA-binding protein which associates with polyribosomes.
• It associates with polyribosomes, predominantly with 60S large ribosomal subunits.
• One site of mRNA translation is at polyribosomes selectively localized beneath synapses.
• Polyribosomes are a prominent feature in the lymphocytes and can be viewed with an electron microscope.
• Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation of mRNA.
• The presence of polyribosomes in spines also suggests protein translational activity in the spine itself, not just in the dendrite.
• In cell biology, "'membrane bound polyribosomes "'are attached to a cell's endoplasmic reticulum.
• Nissl staining uses aniline basic dyes to intensely stain the acidic polyribosomes in the rough endoplasmic reticulum, which is abundant in neurons.
• When the major vault protein ( MVP ) is expressed in insect cells, vault particles are assembled on polysomes ( polyribosomes ) in the cytoplasm.
• A high amount of protein synthesis occurs in this region, as it contains a large number of Nissl granules ( which are ribosomes wrapped in RER ) and polyribosomes.
• Following transcription, Arc mRNA is transported out of the nucleus and localized to neuronal dendrites a process dependent on the 3'UTR, and ERK phosphorylation . and likely translocated into dendritic spines by the actin-based motor protein myosin-Va . Arc has been shown to be associated with polyribosomes at synaptic sites, and is translated in isolated synaptoneurosomal fractions " in vitro " indicating that the protein is likely locally translated " in vivo ".