pouchitis การใช้

• Extreme cramping and pain can occur with pouchitis.
• Patients with pouchitis typically present with bloody diarrhea, urgency in passing stools, or discomfort while passing stools.
• A variety of pathophysiological mechanisms have been proposed for pouchitis, but the precise pathogenesis ( biological cause ) remains unknown.
• The FDA has granted Fast Track Designation to alicaforsen for the treatment of chronic and recurrent pouchitis in recognition of unmet need.
• Endoscopy in patients with pouchitis usually reveals erythematous pouch mucosa, loss of pseudocolonic vasculature or other architecture, and friability of the mucosa.
• The incidence of a first episode of pouchitis at 1, 5 and 10 years post-operatively is 15 %, 33 % and 45 % respectively.
• In April 2009, Atlantic was granted orphan drug status for the product in the treatment of pouchitis in Europe by the European Medicines Agency ( EMA ).
• "Pouchitis ", a term coined by Kock to describe the reservoir ileitis seen in recipients of any pouch procedure, is a common one.
• In June 2008, Atlantic was granted orphan drug status for alicaforsen in the treatment of pouchitis in the USA by the US Food and Drug Administration ( FDA ).
• Additionally, these symptoms are not necessarily specific for pouchitis, asthey may arise from other inflammatory or functional pouch disorders such as Crohn's disease of the pouch, cuffitis, pouch sinus, or irritable pouch syndrome.
• A pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon ran by Croagh C, Shepherd SJ, Berryman M, Muir JG, Gibson PR indicates there might be a relation between Pouchitis and FODMAP content of diets.
• The duration of pouchitis is defined as acute ( less than or equal to four weeks ) or chronic ( four weeks or more ) and the pattern classified as infrequent ( 1-2 acute episodes ), relapsing ( three or fewer episodes ) or continuous.
• Antisense oligonucleotides have been researched as potential drugs for diseases such as cancers ( including lung cancer, colorectal carcinoma, pancreatic carcinoma, malignant glioma and malignant melanoma ), diabetes, Amyotrophic lateral sclerosis ( ALS ), Duchenne muscular dystrophy and diseases such as asthma, arthritis and pouchitis with an inflammatory component.