progestational การใช้

• Dydrogesterone has selective progestational activity and does not inhibit ovulation.
• "To obtain a progestational drug with the wanted properties, it appeared necessary to alter the progesterone molecule itself.
• The new progestational agent was [ 6?-methyl-17?-hydroxyprogesterone acetate ] or [ medroxyprogesterone acetate ], which Upjohn has trademarked Provera.
• It showed that women who took a combination of the estrogen ethinyl estradiol and the progestational agent norethindrone acetate experienced a dose-related increase in bone mineral density over a period of two years.
• It has proved to be the most potent progestational drug yet uncovered  hundreds of times more active orally than progesterone and, weight for weight, some fifty times more active by subcutaneous injection.
• Estrogen without a progestational agent is no longer recommended for women who still have a uterus, since unopposed estrogen can stimulate the growth of the uterine lining and increase a woman's risk of developing endometrial cancer.
• In 1935, at the time of the " Second International Conference on the Standardization of Sex Hormones " in London, England, a compromise was made between the groups and the name progesterone ( progestational steroidal ketone ) was created.
• It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.