prontosil การใช้

• The Prontosil form of sulfa was introduced in 1935 ., and was effective against streptococci.
• As a result, Prontosil failed to make the profits in the marketplace hoped for by Bayer.
• In 1935, Leonard Colebrook showed Prontosil was effective against haemolytic streptococcus and hence a cure for puerperal fever.
• The detailed description says the red ppt is Prontosil and that Zn powder catalyses the reduction of nitrate to nitrite.
• The Bayer company spent a fortune developing a drug " Prontosil " in 1935, which was effective against strep.
• Gerhard Domagk was awarded the Nobel Prize in Physiology or Medicine in 1939 " for the discovery of the antibacterial effects of prontosil ".
• He found the sulfonamide Prontosil to be effective against streptococcus, and treated his own daughter with it, saving her the amputation of an arm.
• Prontosil's discovery ushered in the era of antibacterial drugs and had a profound effect on pharmaceutical research, drug laws, and medical history.
• In the 1930s, IG Farben scientists Gerhard Domagk, Fritz Mietzsch, and Joseph Klarer, discovered prontosil, the first commercially available antibacterial drug.
• "' Prontosil "'is an antibacterial drug discovered in 1932 by a research team at the Bayer Laboratories of the IG Farben conglomerate in Germany.
• Likewise, prontosil, the first sulfa drug ( discovered by Gerhard Domagk in 1932 ), must be cleaved in the body to release the active molecule, sulfanilamide.
• It was " plain old sulfa, " not " plain old sulfur " that was " just as effective " as the newly introduced ( in 1935 ) Prontosil.
• In 1939, Gerhard Domagk ( 1895 1964 ) received the Nobel Prize in Medicine ( see Nobel Prize Website ) " for the discovery of the antibacterial effects of prontosil ".
• "' Prontosil, "'as Bayer named the new drug, was the first medicine ever discovered that could effectively treat a range of bacterial infections inside the body.
• This work, also based in the testing of compounds available from the German dye industry, led to the development of Prontosil, the first representative of the sulfonamide class of antibiotics.
• The crucial test result ( in a murine model of " Streptococcus pyogenes " systemic infection ) that preliminarily established the antibacterial efficacy of Prontosil in mice dates from late December 1931.
• Although quickly eclipsed by these newer " sulfa drugs " and, in the mid-1940s and through the 1950s by penicillin and other antibacterials that proved more effective against more types of bacteria, Prontosil remained on the market until the 1960s.
• It has been argued that IG Farben might have made its breakthrough discovery with sulfanilamide in 1932 but, recognizing that it would not be patentable as an antibacterial, had spent the next three years developing Prontosil as a new, and therefore more easily patentable, compound.
• The readily water-soluble sodium salt of sulfonamidochrysoidine, which gives a burgundy red solution and was trademarked Prontosil Solubile, was clinically investigated between 1932 and 1934, first at the nearby hospital at Wuppertal-Elberfeld headed by Philipp Klee, and then at the D黶seldorf University Hospital.
• Bayer also introduced phenobarbital, prontosil, the first widely used antibiotic and the subject of the 1939 Nobel Prize in Medicine, the antibiotic Cipro ( ciprofloxacin ), and Yaz ( drospirenone ) MSD's consumer business, with brands such as Claritin, Coppertone and Dr . Scholl's.