proteolipid การใช้

• This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca 2 +-ATPases.
• Na / K-consists of an ?-and a ?-subunit ( plus a proteolipid, called ?-subunit ).
• The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.
• In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and / or function.
• These involve the hepatitis B virus mimicking the human proteolipid protein ( myelin protein ) and the Epstein-Barr virus mimicking anti-myelin oligodendrocyte glycoprotein ( contributes to a ring of myelin around blood vessels ).
• His method led to the identification of myelin proteolipid ( defined as a new type of lipoproteins ) in white matter and water-soluble glycolipids ( named strandin at that time but now recognized as gangliosides ) in gray matter.
• Some of the proteins are myelin basic protein ( MBP, which makes up ~ 30 % of myelin protein ), myelin oligodendrocyte glycoprotein, and proteolipid protein ( PLP, which makes up ~ 50 % of myelin protein ).
• As an example, Leone et al . have placed the transcription unit under the control of the regulatory sequences of the myelin proteolipid protein ( PLP ) gene, leading to induced removal of targeted gene sequences in oligodendrocytes and Schwann cells.
• In V-ATPases, there are three proteolipid subunits ( c, c2 and c2 2 ) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane.
• Theiler's murine encephalomyelitis virus ( TMEV ) leads to the development in mice of a progressive CD4 + T cell-mediated response after these cells have infiltrated the CNS . This virus has been shown to cause CNS disease in mice that resembles multiple sclerosis, an autoimmune disease in humans that results in the gradual destruction of the myelin sheath coating axons of the CNS . The TMEV mouse virus shares a thirteen amino acid sequence ( His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe ) ( PLP ( proteolipid protein ) 139-151 epitope ) with that of a human myelin-specific epitope.