proteosome การใช้

• This protein is believed to be active in the proteosome pathway.
• The alpha-synuclein-ubiquitin complex cannot be directed to the proteosome.
• The proteosome is present in every human cell.
• Aging cells may not have the energy to run the proteosome or ubiquitin system.
• Proteosome caused defected degradation is another mechanism.
• C7orf25 protein UPF0415 is believed to be active in ATP dependent protein breakdown in the proteosome pathway.
• This primes the subsequent destruction of the virus by the enzymes of the cell's proteosome system.
• The proteosome is like a salami slicer, said Dr . Ron Kopito, an associate professor of biology at Stanford.
• Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for 26S proteosome.
• Proteosome analysis revealed that Hsp90 is differentially expressed between ewing s sarcoma cell lines, sensitive and resistant to specific IGF1R / KIT inhibitors.
• This theory emphasizes the abnormal intracellular accumulation of many proteins, protein aggregation and misfolding, proteosome inhibition, and endoplasmic reticulum ( ER ) stress.
• A second system tags misfolded proteins with a molecule called ubiquitin and carries them to a garbage disposal _ a barrel-shaped structure called the proteosome.
• By creating a chemical compound to block the function of the proteosome, Adams could see what went wrong and understand the role it played in keeping cells healthy.
• Increasing concentrations of cholesterol ( and other sterols ) cause a change in this domain's oligomerization state, which makes it more susceptible to destruction by the proteosome.
• Among these was ProScript Inc . ProScript discovered Velcade, an inhibitor of the proteosome, that has proved to be an effective treatment for multiple myeloma and other cancers.
• Other proteins that are known to interact with UPF0415 protein C7orf25 are FRA10AC1, TUBB ( tubulin, beta class I ) and only TUBB is associated with proteosome activity.
• This complex is usually called the " beta-catenin destruction complex ", although it is distinct from the proteosome machinery actually responsible for ?-catenin degradation.
• These include transcription factors that initiate gene expression, kinases that transmit information by post-translationally modifying other proteins and E3-ligases that target proteins for degradation via the proteosome.
• Around the same time, however, a group of Israeli researchers discovered that the proteosome contributed to cell division, suggesting to Adams that ProScript's research might have applications in cancer.
• The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.