pseudomonal การใช้

• Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population.
• Only inhalant anthrax and pseudomonal infections in cystic fibrosis infections are licensed indications in the UK due to ongoing safety concerns.
• A 2015 meta analysis concluded that the anti-pseudomonal penicillin-beta lactamase inhibitor combination piperacillin-tazobactam gives results equivalent to treatment with a carbapenem in patients with sepsis.
• None of its drug candidates has been approved, but the farthest along is an inhalant version of tobramycin, a drug used to treat the recurring pseudomonal infections that strike cystic fibrosis patients.
• An antimicrobial effective against Gram-negative enteric bacilli ( i . e . aminoglycoside ) or an anti-pseudomonal cephalosporin ( i . e . cefepime ) are generally added to metronidazole, and occasionally cefoxitin when treating intra-abdominal infections to provide coverage for these organisms.
• Empirical regimens must contain antibiotics broadly active against Gram-negative aerobic bacteria ( quinolones : i . e ., ciprofloxacin, levofloxacin, a third-or fourth-generation cephalosporin with pseudomonal coverage : e . g ., cefepime, ceftazidime, or an aminoglycoside : i . e . gentamicin, amikacin ).