pteridine การใช้

• Chemically, its structure is that of a reduced pteridine derivative.
• Pteridine is a precursor in the synthesis of dihydrofolic acid in many microorganisms.
• "' Pteridine "'is an aromatic chemical compound composed of fused pyrimidine and pyrazine rings.
• The enzyme dihydropteroate synthetase converts pteridine and 4-aminobenzoic acid to dihydrofolic acid in the presence of glutamate.
• Thus, hydride molecules are transferred from NADPH to the C6 position of the pteridine ring to reduce folic acid to THF.
• A "'pteridine "'is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure.
• Part of this pathway is familiar-the red and yellow pigments are pteridine ( biopterin and sepiapterin ) which occur widely in nature.
• The oxygen incorporated need not be derived from O2 with reduced pteridine as one donor, and incorporation of one ato of oxygen into the other donor.
• Then the age of the flies can be specifically determined, using technique such as pteridine fluorescence, and this helps to establish the time of death.
• The bright yellow eyes of the great horned owl are thought to be due to the presence of the pteridine pigment xanthopterin within certain chromatophores ( called xanthophores ) located in the iris stroma.
• PAH is one of three members of the biopterin-dependent aromatic amino acid hydroxylases, a class of monooxygenase that uses tetrahydrobiopterin ( BH 4, a pteridine cofactor ) and a non-heme iron for catalysis.
• Some " Russula " species contain pigmented " pteridine " derivatives called " russupteridines " that are not found in the milk-caps . " Sesquiterpenes " are characteristic secondary metabolites of many Russulaceae, especially milk-caps which have been quite intensively studied.
• The folate binding pocket is delineated by pteridine-binding cleft, the formyl transfer region and the benzoylglutamate region which bind thepteridine head and a benzoylglutamate tail connected by a formyl bound nitrogen of fTHF . This folate binding region has been the subject of much research because its inhibition by small molecules has led to the discovery of antineoplastic drugs.