quinolinate การใช้

• It is synthesised by the oxidation of aspartate and is condensed by quinolinate synthase with glycerone phosphate to form quinolinic acid.
• This is followed by a condensation with glyceraldehyde-3-phosphate and a cyclization catalyzed by quinolinate synthase ( QS ) to give quinolinic acid.
• Quinolinate is a neurotoxin formed nonenzymatically from 2-amino-3-carboxymuconic semialdehyde in mammalian tissues . 2-Amino-3-carboxymuconic semialdehyde is enzymatically converted to 2-aminomuconate via 2-aminomuconic semialdehyde.
• Third, it may be caused by excess leucine, as it inhibits quinolinate phosphoribosyl transferase ( QPRT ) and inhibits the formation of Niacin or Nicotinic acid to Nicotinamide mononucleotide ( NMN ) causing pellegra like symptoms to occur.