quinuclidine การใช้

• Many derivatives of quinuclidine such as quinuclidine amide are known to be ?7 nAChR agonists.
• Many derivatives of quinuclidine such as quinuclidine amide are known to be ?7 nAChR agonists.
• The quinoline and quinuclidine rings are sterically demanding groups that can induce a high degree of stereoselectivity.
• SAR studies for quinuclidine amide have identified factors that are affecting the potency and affinity of these agonists.
• Para substitution on the quinuclidine ring and the 3-( R ) configuration in the stereochemistry is favored.
• "' Quinuclidine "'is an organic compound and a bicyclic amine and used as a catalyst and a chemical building block.
• The rigidity of quinuclidine and the orthogonal orientation of the nitrogen bridge in relations to the amide carbonyl group is presumed important for the optimal binding.
• An extended resorcin [ 4 ] arene cavitand is found to accelerate the reaction rate of a Menshutkin reaction between quinuclidine and butylbromide by a factor of 1600.
• The tertiary amine contained within the quinuclidine can act as a nucleophile that attacks the most electrophilic carbon of the ketene to promote the formation of ?-lactams.
• The stability of some of the more potent quinuclidine amide derivatives in rat " in vitro " models have been low however by adding a methyl group to position 2 on the quinuclidine ring the stability has increased greatly.
• The stability of some of the more potent quinuclidine amide derivatives in rat " in vitro " models have been low however by adding a methyl group to position 2 on the quinuclidine ring the stability has increased greatly.
• The key areas of specialization in final dosage forms include neurology ( cholinesterase inhibitors, anxiolytics, psychostimulants, nootropics ), cardiology ( antiarrhythmics, energy metabolism enhancers ), infectology ( original nitrofurantoine derivatives and adamantine, quinuclidine and nitrofurane chemistry.