rptor การใช้

• RPTOR is an evolutionarily conserved protein with multiple roles in the mTOR pathway.
• Amino acid availability determines RPTOR targeting to lysosomes.
• RPTOR also has a positive role in maintaining cell size and mTOR protein expression.
• RPTOR is overexpressed in pituitary adenoma, and its expression increases with tumor staging.
• In the cell, RPTOR is present in cytoplasm, lysosomes, and cytoplasmic granules.
• Astrin recruits RPTOR to stress granules, inhibiting mTORC1 association and preventing apoptosis induced by mTORC1 hyperactivation.
• The association of mTOR and RPTOR is stabilized by nutrient deprivation and other conditions which suppress the mTOR pathway.
• "RPTOR " encodes part of a signaling pathway regulating cell growth which responds to nutrient and insulin levels.
• In stressed cells, RPTOR associates with SPAG5 and accumulates in stress granules, which significantly reduces its presence in lysosomes . ..
• RPTOR is highly expressed in skeletal muscle and is somewhat less present in brain, lung, small intestine, kidney, and placenta tissue.
• RPTOR could be valuable in the prediction and prognosis of pituitary adenoma due to this correlation between protein expression and the growth and invasion of the tumor.
• Therefore, mTOR, RPTOR and RICTOR were significantly correlated with the growth and invasion of pituitary adenomas and may have an important predictive and prognostic value in such patients.
• AMPK inhibits the energy-intensive protein biosynthesis process and can also force a switch from cap-dependent translation to cap-independent translation, which requires less energy, by phosphorylation of TSC2, RPTOR, transcription initiation factor 1A . 66, and eEF2K.