secretase การใช้

• Amgen is now looking for compounds that can block the beta secretase.
• Gamma secretase activity has also been associated with lipid rafts.
• It is an inhibitor of beta-secretase 1 ( BACE1 ).
• Its drug candidate blocks an enzyme called gamma secretase.
• This can come about by various effects of the mutations upon gamma secretase.
• But he argued that presenilin 1 might just be an accessory to gamma secretase.
• The amyloid-? peptide is derived from the cleavage of APP by gamma secretase.
• Recent research has shown that interaction of the gamma secretase complex with the ?-amyloid.
• Cell-surface cleavage by alpha secretase is very rapid after APP reaches the cell surface.
• The drug semagacestat in contrast to imatinib, works by directly inhibiting the ?-secretase.
• Alpha secretase activity has also been observed to be upregulated in response to the signaling peptide PACAP.
• Initial cleavage of APP by ?-secretase rather than BACE1 prevents eventual generation of amyloid-?.
• The search for beta-secretase has been littered with claims of discovery that were disputed, then discarded.
• The SmithKline Beecham researchers suspected that beta-secretase belonged to a family of proteins known as aspartic proteases.
• The same step can be also blocked by several gamma-secretase inhibitors, shown in the same study.
• In theory, scientists could stop A beta production by blocking either the beta-or the gamma-secretase.
• Big hopes also rest on secretase inhibitors, designed to prevent the beta amyloid protein forming in the first place.
• ApoE binding leads to the cleavage of ApoER2 into secreted proteins by the actions of the plasma membrane protein gamma secretase.
• Gamma secretase is a protein complex thought to be a fundamental building block in the development of the amyloid beta peptide.
• A gamma secretase inhibitor, semagacestat, failed to show any benefit to Alzheimer's disease patients in clinical trials.