squalamine การใช้

• But, depending on further research, squalamine might be given as pills.
• If additional animal experiments are fruitful, human tests of squalamine might start in a year.
• Subsequently his group discovered squalamine to be a potent antiangiogenic compound with activity against solid tumors.
• Such experiments would be intended to test squalamine's safety, not its effectiveness in humans.
• The findings provide " the first evidence that squalamine may work against brain cancer,"
• So is squalamine, derived from the liver of the dogfish shark, along with several others.
• The team hopes that squalamine may ultimately be used with standard chemotherapy, radiation and surgery in treating brain tumors.
• Squalamine, a new substance found in sharks, has shown promise in slowing the growth of brain tumors in rats.
• In 1993 Zasloff reported the discovery of the aminosterol squalamine from the dogfish shark, " Squalus acanthias ".
• And if human tests succeed, squalamine may be added to standard chemotherapy, radiation and surgery . _ LAWRENCE K . ALTMAN
• The experiments with squalamine, which Brem obtained as a synthetic chemical and not from sharks, were undertaken for a quite different reason.
• The livers and stomachs of the Squalidae contain the compound squalamine, which possesses the property of reduction of small blood vessel growth in humans.
• Other scientists have determined that squalamine works by changing a cell's shape through disruption of the exchange of sodium and hydrogen on its surface.
• If squalamine is tested in humans, it will join several other experimental drugs that block formation of new blood vessels and are being tested against several ailments.
• Squalamine is currently in Phase II clinical trials being evaluated by Ohr Pharmaceuticals, Inc . for the topical treatment of wet age related macular degeneration ( AMD ).
• In 1991, while at Penn, Dr . Zasloff and his group discovered squalamine in tissues of the dogfish shark, the first of a novel class of steroids, called aminosterols.
• Additional animal experiments must be completed before squalamine can be tested in humans, and it will be at least a year before the Food and Drug Administration is likely to allow clinical tests to begin.
• Brem's team carried out several types of experiments, some still in progress, to show that squalamine inhibits formation of new blood vessels induced by a type of brain tumor known as a glioma.
• Magainin began testing squalamine and other shark-derived substances as drugs against infection, but because of the chemical's ability to block blood-vessel growth, Zasloff asked Brem to explore its effect against cancer.
• Squalamine was found to be a component of shark stomach and other tissues by Dr . Michael Zasloff, of Magainin Pharmaceuticals in Plymouth Meeting, Pa ., in the course of his search for natural antibiotics in the animal kingdom.