streptogramin การใช้

• Quinupristin and dalfopristin are both streptogramin antibiotics, derived from pristinamycin.
• They fall into two groups : streptogramin A and streptogramin B.
• They fall into two groups : streptogramin A and streptogramin B.
• Pristinamycin IIA ( streptogramin A ) is a depsipeptide.
• The figure below shows the origins of the synthetic components of streptogramin A.
• Multiple mechanisms of streptogramin resistance have developed despite Synercid's fairly recent development.
• Streptogramin B prevents the elongation of protein chains and causes the release of incomplete peptides.
• "' Linopristin "'is an antibiotic of the streptogramin B class.
• Streptogramin A is a polyketide in nature, but contains some amino acid components as well.
• Other enzymes are required for tailoring of streptogramin A, particularly for the unusual methylation reaction.
• "' Pristinamycin IIB "'is an antibiotic of the streptogramin A class.
• "' Virginiamycin "'is a streptogramin antibiotic similar to pristinamycin and quinupristin / dalfopristin.
• Streptogramin A first binds to the peptidyl transferase domain of the 50s ribosomal subunit, preventing the early events of elongation.
• The binding of streptogramin A causes a conformational change that increases the ribosomal binding activity of streptogramin B 100-fold.
• The binding of streptogramin A causes a conformational change that increases the ribosomal binding activity of streptogramin B 100-fold.
• The biosynthesis of streptogramin B is carried out by large multifunctional enzymes called non-ribosomal peptide synthetases ( NRPS ).
• "' Dalfopristin "'is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A ( Enterococcus faecium ".
• It is a member of the streptogramin B group of antibiotics and one component of pristinamycin ( the other being pristinamycin IIA ).
• It is a member of the streptogramin A group of antibiotics and one component of pristinamycin ( the other being pristinamycin IA ).
• The molecular target of streptogramins is the 23S rRNA . Both streptogramin A and B bind to the P binding site of the 50S ribosome subunit.