stromelysin การใช้

• The cDNA of MMP7 is 49 % homologous to stromelysin-1.
• Another study showed that release of HS-bound basic FGF in culture could be achieved through treatment with stromelysin, heparitinase I, rat collagenase and plasmin, and these proteolysis sites are illustrated in figure 1.
• MMP-27 could be classified in the stromelysin group of MMPs, since MMP-27 shows 51, 6 % homology with stromelysin-2 ( MMP-10 ) and localizes in the cluster of MMPs located on chromosome 11.
• MMP-27 could be classified in the stromelysin group of MMPs, since MMP-27 shows 51, 6 % homology with stromelysin-2 ( MMP-10 ) and localizes in the cluster of MMPs located on chromosome 11.
• The human MMP7 is located on chromosome 11 q22.3 . " MMP " genes are clustered in q region of human Chromosome 11 including " matrilysin, collagenase-1, stromelysin1, stromelysin-2, and metalloelastase " genes.
• The expression of MMP7 is regulated by the Wnt / ? catenin signaling pathway, and mediated by transformation growth factor ? ( TGF-? ) . TGF-? stimulates ECM and suppresses the steady-state level of MMP7, stromelysin mRNAs, and secretion of zymogens.
• "' ESAC "'technology has been used for the isolation of potent inhibitors of stromelysin-1 ( MMP-3 ), a matrix metalloproteinase involved in both physiological and pathological tissue remodeling processes, as well as in disease processes, such as arthritis and metastasis.
• Matrix metalloproteinases ( MMP ), which catalyse extracellular matrix degradation, have N-terminal domains that resemble PGBD . Examples are gelatinase A ( MMP-2 ), which degrades type IV collagen, stromelysin-1 ( MMP-3 ), which plays a role in arthritis and tumour invasion, and gelatinase B ( MMP-9 ) secreted by neutrophils as part of the innate immune defence mechanism.