temozolomide การใช้

• Other cell division inhibitors commonly used in studies are cytarabine and temozolomide.
• Tetrazines include dacarbazine, mitozolomide and temozolomide.
• Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide.
• Irinotecan ( intravenous or oral ) and oral temozolomide are also used in refractory and recurrent neuroblastoma.
• Only small lipophilic alkylating agents such as lomustine or temozolomide are able to cross this blood brain barrier.
• The standard dosing schedule of temozolomide is 5 consecutive days of daily dosing during 28-day cycles.
• Long-term benefits have also been associated with those patients who receive surgery, radiotherapy, and temozolomide chemotherapy.
• Indeed, MGMT methylation is associated with an improved response to treatment with DNA-damaging chemotherapeutics, such as temozolomide.
• High doses of temozolomide in high-grade gliomas yield low toxicity, but the results are comparable to the standard doses.
• Earlier this year, the Swiss scientists reported that giving temozolomide to patients early in treatment could prolong the lives of some patients.
• "These results are important because temozolomide is a drug that acts directly against DNA to slow down the replication of cancer cells.
• One such approach permanently fused perillyl alcohol, a natural compound with demonstrated therapeutic activity in brain cancer patients, to the temozolomide molecule.
• In the laboratory, this combination indeed showed increased temozolomide activity in tumor-cell culture in vitro and in animal models in vivo.
• Combinations of several medicines have been used, such as doxorubicin with streptozocin and fluorouracil ( 5-FU ) and capecitabine with temozolomide.
• This would allow for the patients to receive stronger doses of temozolomide, since the patient's hematopoietic cells would be resistant to the drug.
• Temodar, known chemically as temozolomide, is an oral form of chemotherapy for adults with anaplastic astrocytomas, giving patients the ability to be treated by taking pills at home.
• MIC is used in the synthesis of Fluzinamide, Caracemide, cloretazine, temozolomide & 1, 1-diphenyl-2-propynyl n-methylcarbamate ( analog of Enpromate ).
• Dacarbazine, temozolomide, and cisplatin all have a reproducible 10 20 % response rate in metastatic melanoma .; however, these responses are often short-lived and almost never complete.
• The resultant novel compound, called NEO212 or TMZ-POH, revealed anticancer activity that was significantly greater than that of either of its two parent molecules, temozolomide and perillyl alcohol.
• While the above-mentioned approaches have investigated whether the combination of temozolomide with other agents might improve therapeutic outcome, efforts have also started to study whether altering the temozolomide molecule itself can increase its activity.