teniposide การใช้

• Podophyllum ( Etoposide ?Teniposide ); 3a.
• Podophyllotoxin is used to produce two other drugs with different mechanisms of action : etoposide and teniposide.
• Mayapple can be also used topically for warts, and two of its derivatives, etoposide and teniposide, have shown promise in treating some malignant neoplasms.
• The latter two compounds teniposide and etoposide were found by St鋒elin to have a new mechanism of action : they blocked the entry of cells into mitosis ( arrest in late S or G2 ) in contrast to SP-G and SP-I, respectively, which were spindle poisons.
• After a landmark clinical comparative analysis by F . Muggia and M . Rozencweig ( Cancer 40 ( 1 ), 334-42, 1977 ) etoposide and teniposide were licenced to Bristol-Myers in 1978 for further clinical development which rapidly brought etoposide's US-FDA approval in November 1983.
• Teniposide and etoposide were found by St鋒elin to have a new mechanism of action : they blocked the entry of cells into mitosis ( with arrest in late S or G2 phase ), in contrast to SP-G and SP-I, which were U . S . Food and Drug Administration.
• Further chemical modifications led to the well-known thenylidene derivative VM-26 ( teniposide, VumonR, discovered in October 1965, commercialized by Sandoz in 1976 ) and to the clinically still very successful ethylidene derivative VP-16-213 ( etoposide, VepesidR, discovered on October 21, 1966 ).
• Further chemical modifications led to the well-known thenylidene derivative VM-26 ( teniposide, Vumon, discovered in October 1965, commercialized by Sandoz in 1976 ) and to the ethylidene derivative VP-16-213 ( etoposide, Vepesid, discovered on October 21, 1966 ), which remains very clinically successful.