thrombogenic การใช้

• Also, they are the least thrombogenic of the artificial valves.
• This arachidonic acid is then metabolized to form several inflammatory and thrombogenic molecules.
• Circulating microvesicles isolated from cardiac surgery patients were found to be thrombogenic in both in vitro assays and in rats.
• By inducing thrombogenic state through vasoconstriction of the microvasculature, tobacco influences blood flow, wound healing and the survival of pedicled flaps.
• Merrill's ideas on poly ( ethylene oxide ) ( PEO ) as a non-thrombogenic biomaterial ( 1979 with Saltzman)
• Ruptures of the fibrous cap expose thrombogenic material, such as collagen, to the circulation and eventually induce thrombus formation in the lumen.
• Guide wires with hydrophilic coatings have increased trackability and are not very thrombogenic; however the low coefficient of friction increases the risk of the wire slipping and perforating the artery.
• Not only is the coating non-thrombogenic, but it also exhibits other features that should be present when applying such a material to a medical device for long-term implantation.
• Red blood cells and fibrin are the main components of venous thrombi, and the thrombi appear to attach to the blood vessel wall endothelium, normally a non-thrombogenic surface, with fibrin.
• A thrombogenic implant will eventually be covered by a fibrous capsule, the thickness of this capsule can be considered one measure of thrombogenicity, and if extreme can lead to the failure of the implant.
• The extracellular matrix of the lesion breaks, usually at the shoulder of the fibrous cap that separates the lesion from the arterial lumen, where the exposed thrombogenic components of the plaque, mainly collagen will trigger thrombus formation.
• The Shiga-toxin-activated endothelial cells then become thrombogenic ( clot-producing ) by mechanism that is not fully understood, though they have been shown to induce the release of cytokines and chemokines that are implicated in platelet activation.
• Even though it is present at only 5 10 % the levels of ?-antithrombin, due to its increased heparin affinity, it is thought that ?-antithrombin is more important than ?-antithrombin in controlling thrombogenic events resulting from tissue injury.
• In general, hormone replacement therapy is somewhat controversial due to the known carcinogenic and thrombogenic properties of estrogen; however, many physicians and patients feel the benefits outweigh the risks in women who may face serious health and quality of life issues as a consequence of early surgical menopause.
• The first application of this approach for use on stents evolved from efforts by "'Hayward and Chapman " " " " et al . " "', who demonstrated that the phosphorylcholine component of the outer surface of the erythrocyte bilayer was non-thrombogenic.
• When the fibrous cap is degraded by metalloproteinases released from macrophages or by intravascular shear force from blood flow, subendothelial thrombogenic material ( extracellular matrix ) is exposed to circulating platelets and thrombus formation occurs on the vessel wall embolus which travels with the blood-flow downstream to where the vessel narrows and eventually clogs the vessel lumen.