thromboxane การใช้

• Aspirin inhibits platelet aggregation by inhibiting the action of thromboxane A 2.
• This isomerization mechanism shows prostaglandin H2 being converted to thromboxane.
• Thromboxane A2 ( TX2 ) has a positive feedback in platelet activation.
• Receptors that mediate TXA2 actions are thromboxane A2 receptors.
• The prototype for these drugs is aspirin, which inhibits the production of thromboxane.
• Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist.
• Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist.
• Thromboxane A ( TXA ) is derived from the prostaglandin H2 ( PGH2 ) molecule.
• An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.
• Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation.
• The toxin-induced contraction was related to generation of thromboxane A 2 from arachidonic acid.
• It is associated with a deficiency of Thromboxane-A synthase, which produces Thromboxane A2.
• It is associated with a deficiency of Thromboxane-A synthase, which produces Thromboxane A2.
• Thromboxane is thought to cause platelets in the blood to stick together, leading to blood clots.
• In this case, the greater aggregation of platelets produce ADP, serotonin, and thromboxane A2.
• Eikelboom theorized that aspirin did not adequately block thromboxane in some patients because of an underlying genetic mutation.
• The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.
• It is produced by the oxygenation of arachidonic acid by two enzymes : cycloxygenase and thromboxane A2 synthase.
• The researchers analyzed urine samples of 5, 529 heart patients in Canada for a chemical byproduct of thromboxane.
• Testosterone also regulates the population of thromboxane A 2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.