thymidylate การใช้

• It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca.
• Another protein encoded by the genome is thymidylate kinase.
• Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
• LSF and Thymidylate synthase plays significant role in Liver Cancer proliferation and progression and Drug resistance.
• Thymidylate synthase ( TS ) plays a crucial role in the early stages of DNA biosynthesis.
• "' OSI-7904L "'is a novel noncompetitive liposomal thymidylate synthase inhibitor.
• Thymidylate kinase can phosphorylate TMP into thymidine diphosphate, which nucleoside diphosphate kinase can phosphorylate into thymidine triphosphate.
• These are required for thymidylate and purine production, which are both essential for DNA synthesis and cell division.
• Thymidylate synthase is induced by a transcription factor LSF / TFCP2 and LSF is an oncogene in hepatocellular carcinoma.
• This gene encodes a protein that possesses three distinct enzymatic activities, thymidylate, and de novo purine syntheses.
• FUMP becomes incorporated into RNA and fdUMP inhibits the enzyme thymidylate synthase; both of which lead to cell death.
• Tetrahydrofolate and its derivatives are essential for purine and thymidylate synthesis, which are important for cell proliferation and cell growth.
• Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis.
• After creation of the dTMP molecule, another kinase, thymidylate kinase, can act upon dTMP to create the clinical chemistry.
• Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 and thymidylate synthase are not cell cycle-dependent.
• It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide formyltransferase and glycinamide ribonucleotide formyltransferase.
• To be specific, it is the C1-donor in the reactions catalyzed by thymidylate synthase and thymidylate synthase ( FAD ).
• To be specific, it is the C1-donor in the reactions catalyzed by thymidylate synthase and thymidylate synthase ( FAD ).
• One of the important targets for cellular reproduction is thymidylate synthase, which creates thymidine monophosphate ( TMP ) from deoxyuridine monophosphate ( dUMP ).
• Specifically, it converts the intermediate metabolite 5-deoxy-5-fluorocytidine in tumors to 5-fluorouracil, which acts as a thymidylate synthase inhibitor.