thymosins การใช้

• The growth of actin filaments can be regulated by thymosin and profilin.
• Thymosin ? 4 was initially perceived as a thymic hormone.
• In relation to diseases, thymosins have been categorized as biological response modifiers.
• The proteins thymosin and profilin prevent the spontaneous nucleation of new actin trimers.
• But precisely how thymosin works remains unclear.
• "' Thymosins "'are small proteins present in many animal tissues.
• Taken together, these effects suggest that thymosin has a general role in tissue regeneration.
• Thymosin ? 4 functions like a buffer for monomeric actin as represented in the following reaction:
• It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.
• Other proceedings are active before Australian courts regarding Dank's supply of Thymosin Beta on sportsmen.
• Researchers said other questions about thymosin must be resolved before it could be used as a heart attack remedy.
• It is considered unlikely that thymosin ? 4 exerts all these effects via intracellular sequestration of G-actin.
• Half of the mice were injected with a dose of thymosin beta 4, while the rest received a placebo.
• Then, T-lymphocytes further mature and differentiate into lymphoblasts when the hormone thymosin is secreted from the thymus.
• Formation by G-actin of the complex with ?-thymosin ( = " sequestration " ) opposes this.
• Although thymosin beta-4 is strictly a monomer-sequestering protein, the behavior of profilin is far more complex.
• When individual thymosins were isolated from Fraction 5 and characterized, they were found to have extremely varied and important biological properties.
• Proteins such as thymosins which lack stable folded structure in aqueous solution, are known as intrinsically unstructured proteins ( IUPs ).
• Thymosin ? 4 induces the activity of the enzyme terminal deoxynucleotidyl transferase in populations of thymocytes ( thymus-derived lymphocytes ).
• Profilin is one of the most abundant actin monomer binders, but proteins such as thymosin ?4 have some functional overlaps with profilin.