tmev การใช้

• The majority of mouse strains are not susceptible to the pathology associated with TMEV infection.
• It may be an important link between the study of mouse TMEV-induced encephalomyelitis and human Multiple Sclerosis.
• As a result, there was a CD4 + T cell response and autoimmune demyelination was initiated by infection with a TMEV peptide ligand.
• To test the efficacy in which TMEV uses molecular mimicry to its advantage, a sequence of the human myelin-specific epitope was inserted into a non-pathogenic TMEV variant.
• To test the efficacy in which TMEV uses molecular mimicry to its advantage, a sequence of the human myelin-specific epitope was inserted into a non-pathogenic TMEV variant.
• A unique feature of this genus is the presence of the L * protein that is made out of frame from the polyprotein and is present in the DA subgroup of TMEV . It has been found to be important for the virus pathogenesis.
• Found to occur in high prevalence ( > 90 % ) among humans, by analogy SAFV may have effects similar to those observed in mouse TMEV-induced encephalomyelitis, in terms of catalyzing the development of human Multiple Sclerosis or other serious diseases because of infection early in life.
• "Cardiovirus A " has only one serotype, while " Cardiovirus B " consists of four viruses which are probably serologically distinct; these are Theiler's Murine encephalomyelitis virus ( TMEV ), Vilyuisk human encephalomyelitis virus ( VHEV ), a Theiler-like rat virus ( TRV ) ( which has yet to be named ) and Saffold virus ( SAF-V ).
• Theiler's murine encephalomyelitis virus ( TMEV ) leads to the development in mice of a progressive CD4 + T cell-mediated response after these cells have infiltrated the CNS . This virus has been shown to cause CNS disease in mice that resembles multiple sclerosis, an autoimmune disease in humans that results in the gradual destruction of the myelin sheath coating axons of the CNS . The TMEV mouse virus shares a thirteen amino acid sequence ( His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe ) ( PLP ( proteolipid protein ) 139-151 epitope ) with that of a human myelin-specific epitope.
• Theiler's murine encephalomyelitis virus ( TMEV ) leads to the development in mice of a progressive CD4 + T cell-mediated response after these cells have infiltrated the CNS . This virus has been shown to cause CNS disease in mice that resembles multiple sclerosis, an autoimmune disease in humans that results in the gradual destruction of the myelin sheath coating axons of the CNS . The TMEV mouse virus shares a thirteen amino acid sequence ( His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe ) ( PLP ( proteolipid protein ) 139-151 epitope ) with that of a human myelin-specific epitope.