transmethylation การใช้

• An example of transmethylation is the recovery of methionine from homocysteine.
• AdoMet is a methyl donor for transmethylation.
• It is expected that the accumulation of homocysteine residues and the impaired transmethylation reactions are underlying factors of spermatogenic failure in male infertility.
• This transmethylation mechanism has been repeatedly and consistently proven by radiolabeling of SAM methyl group with carbon-14 ( 14 C-CH 3 ) SAM ).
• These reactions are also involved in transferring methyl groups, consisting of a carbon atom and three hydrogen atoms, from one molecule to another ( transmethylation ), which is important in many cellular processes.
• In collaboration with the organic chemist John Harley-Mason and Humphry Osmond his psychiatric colleague at St . George s, he developed this idea, into the first specific biochemical theory of schizophrenia the transmethylation hypothesis ( 5 ).
• 2-Hydroxybutyrate, the conjugate base of 2-hydroxybutyric acid, is produced in mammalian tissues ( principally hepatic ) that catabolize L-cysteine for glutathione synthesis become limiting, so homocysteine is diverted from the transmethylation pathway forming methionine into the transsulfuration pathway forming cystathionine . 2-Hydroxybutyrate is released as a byproduct when cystathionine is cleaved to cysteine that is incorporated into glutathione.