triazole การใช้

• For example, phenyl azide and phenylacetylene give diphenyl triazole.
• The triazole bridges do not confer any stability to oligopeptide.
• Fluconazole is a first-generation triazole antifungal medication.
• It has a relatively broad spectrum compared to azole compounds but not triazole compounds.
• It is of the triazole class.
• For invasive disease, treatments include amphotericin B, echinocandins, or extended-spectrum triazole antifungals.
• Triazole has been shown in laboratory studies to effectively control mycelial growth and provides local systemic protection.
• The less toxic and generally more effective triazole antifungal agents fluconazole and itraconazole are usually preferred for systemic use.
• The retro-Diels Alder reaction occurs quickly afterwards to form the stable 1, 2, 3 triazole.
• Finally C9-triazole derivatives of DANA containing an alkoxy group with a nanomolar activity against hNEU4 isoenzyme have been reported.
• Itraconazole ( R51211 ), invented in 1984, is a triazole fungistatic antifungal agent prescribed to patients with fungal infections.
• The groups can be linked to give heterocyclic carbenes, such as those derived from imidazole, imidazoline, thiazole or triazole.
• Newer triazole drugs such as posaconazole or voriconazole have not yet been studied in-depth through clinical trials in this context.
• For vaginal yeast infection in pregnancy, topical imidazole or triazole antifungals are considered the therapy of choice owing to available safety data.
• The triazole plant protection fungicides include epoxiconazole, triadimenol, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.
• 3-AT is also a nonselective systemic triazole herbicide used on nonfood croplands to control annual grasses and broadleaf and aquatic weeds.
• The compound consists of a 1, 2, 4-triazole heterocycle with three functional groups : amine, thioamide, hydrazide.
• It differs from earlier azole antifungals ( such as ketoconazole ) in that its structure contains a triazole ring instead of an imidazole ring.
• The metallacycle intermediate then undergoes reductive elimination releasing the aromatic triazole product and regenerating the catalyst or the activated complex for further reaction cycles.
• Triazole-based carbenes are thermodynamically stable and have diagnostic 13 C NMR chemical shift values between 210 220 ppm for the carbenic carbon.