tryparsamide การใช้

• In 1925, he encouraged use of tryparsamide to cure sleeping sickness.
• Drug advances for sleeping sickness included Germanin and tryparsamide.
• They also investigated the used of tryparsamide as a possible treatment for syphilis.
• Tryparsamide was a standard treatment for syphilis until penicillin replaced it in 1950.
• Variants of tryparsamide, as Flexner named it, continue to be administered today.
• Nonetheless, tryparsamide became the drug of choice for chemotherapy of sleeping sickness for several decades.
• American medical missionary Arthur Lewis Piper was active in using tryparsamide to treat sleeping sickness in the Belgian Congo in 1925.
• Tryparsamide was announced in the " Journal of Experimental Medicine " in 1919 and tested in the Belgian Congo by Louise Pearce of the Rockefeller Institute in 1920.
• Human trials also revealed that a side effect of other arsenical compounds, damage to the optic nerve and loss of vision, could occur with high or repeated doses of tryparsamide.
• There she worked with a local hospital and laboratory to design and carry out a drug testing protocol for human trials to establish tryparsamide's safety, effectiveness, and optimum dosage.
• By 1922, Suramin was generally combined with tryparsamide ( another pentavalent organoarsenic drug ), the first drug to enter the nervous system and be useful in the treatment of the second stage of the gambiense form.
• The trio of physicians at Wisconsin went on to publish more than 100 papers on neurosyphilis; in particular, they developed and refined an alternative to Wagner-Jauregg therapy, using an arsenical medication called tryparsamide.
• The Rockefeller Institute sent Louise Pearce to L & eacute; opoldville in the Belgian Congo in 1920 to test tryparsamide, " trusting her vigorous personality to carry out an assignment none too easy for a woman physician and not without its dangers ".
• Although it was generally much less powerful against spirochetes than against trypanosomes, tryparsamide's ability to pass the blood-brain barrier and enter the central nervous system made it a useful treatment for syphilis of the brain and spinal cord and the chronic form, general paresis.