tyrocidines การใช้

• The antibiotics gramicidin and tyrocidine were first isolated from it.
• The exact affinity and location of tyrocidine within the phospholipid bilayer is not yet known.
• In earlier work with Rene J . Dubos, Hotchkiss helped to develop two antibiotics, gramicidin and tyrocidine.
• Tyrocidine appears to perturb the lipid bilayer of a microbe s inner membrane by permeating the lipid phase of the membrane.
• Tyrocidine has a unique mode of action in which it disrupts the cell membrane function, making it a favorable target for engineering derivatives.
• In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20 % gramicidin and 80 % tyrocidine, from " B . brevis ."