tyrosine aminotransferase การใช้

• Tyrosinemia is the most common metabolic disease associated with tyrosine aminotransferase.
• Tyrosine Aminotransferase as a dimer has two identical active sights.
• The disease results from a deficiency in hepatic tyrosine aminotransferase.
• The conversion from tyrosine to 4-HPPA is in turn catalyzed by tyrosine aminotransferase.
• This metabolite of L-DOPA formed, 3-OMD, is transaminated to vanilpyruvate by tyrosine aminotransferase.
• Each side of the dimer protein includes pyridoxal phosphate ( PLP ) bonded to the "'Lys280 "'residue of the tyrosine aminotransferase molecule.
• "' Tyrosine aminotransferase "'( or "'tyrosine transaminase "') is an enzyme present in the liver and catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate.
• Structures of the three main molecules involved in chemical reaction catalyzed by the tyrosine aminotransferase enzyme are shown below : the amino acid tyrosine, the prosthetic group pyridoxal phosphate, and the resulting product 4-hydroxyphenylpyruvate.