u46619 การใช้

• U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.
• "' U46619 "'is a stable synthetic analog of the endoperoxide prostaglandin PGH 2 first prepared in 1975, and acts as a thromboxane A 2 ( TP ) receptor agonist.
• Most work in the field of TXA2 is done instead with synthetic analogs such as U46619 and I-BOP . In human studies, 11-dehydrothromboxane B2 levels are used to indirectly measure TXA2 production.
• This antagonistic activity was responsible for the ability of 12 ( " S " )-HETE and 12 ( " R " )-HETE to relax mouse mesenteric arteries pre-constricted with a thromboxane A2 mimetic, U46619.
• For example, in HEK-293 cells, TP ? but not TP ? undergoes U46619-induced G protein-coupled receptor ( GRK ) phosphorylation and internalization, whereas the C-terminus of TP? is not capable of being phosphorylated by GRKs.