uncoupler การใช้

• Rottlerin has been shown to be an uncoupler of mitochondrial oxidative phosphorylation.
• It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain.
• Thus it is unlikely that ( + )-totarol is an uncoupler of bacterial respiration at the low levels observed in antimicrobial studies.
• The mode of action involves the compound being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and also having high reactivity with thiols.
• The drug 2, 4-dinitrophenol, which also acts as a chemical uncoupler similarly to UCP1, was used for weight loss in the 1930s.
• You may want to try a less effective uncoupler, preferably one without this many side effects ( e . g . cataracts, and things resulting from intracellular Ca 2 + levels rising unchecked ).