unfractionated การใช้

• Continuous IV unfractionated heparin has been the traditional agent of choice.
• Dalteparin is not superior to unfractionated heparin in preventing blood clots.
• The affinity of unfractionated heparin and the various LMWHs for Factor Xa varies considerably.
• However, unfractionated heparin and low molecular weight heparin do not cross the placenta.
• However, the effects of natural, or unfractionated heparin are more unpredictable than LMWH.
• Still, LMWHs are much less likely to cause heparin-induced thrombocytopenia than unfractionated heparin.
• The drug is usually applied together with aspirin or clopidogrel and ( low molecular weight or unfractionated ) heparin.
• Some of these miscarriages may " potentially " be prevented with the administration of aspirin and unfractionated heparin.
• Unfractionated heparin has the disadvantage of requiring dose adjustment based on a laboratory exam, activated partial thromboplastin time ( APTT ).
• Heparin ( unfractionated heparin ) and its derivatives antithrombin ( AT ) to inactivate several coagulation factors IIa, Xa, XIa and XIIa.
• While unfractionated heparin is otherwise typically given in an intravenous formulation, this is inconvenient for the prolonged period of administration required in pregnancy.
• Lepirudin may be used as an anticoagulant when heparins ( unfractionated or low-molecular-weight ) are contraindicated because of heparin-induced thrombocytopenia.
• Apart from streptokinase, all thrombolytic drugs are administered together with heparin ( unfractionated or low molecular weight heparin ), usually for 24 to 48 hours.
• "' Ciraparantag "'( factor Xa inhibitors ( rivaroxaban, apixaban and edoxaban ), dabigatran, low molecular weight heparins and unfractionated heparin.
• Also, is there any diff between unfractionated heparin and low molecular weight heparin in this regard ? talk ) 13 : 16, 13 August 2008 ( UTC)
• Because LMWH has more predictable pharmacokinetics and anticoagulant effect, LMWH is recommended over unfractionated heparin for patients with massive pulmonary embolism, and for initial treatment of deep vein thrombosis.
• Sequential calf compression and graduated compression stockings are currently the preferred prophylaxis in neurosurgery for the prevention of DVT and pulmonary embolism, sometimes in combination with low molecular weight heparins or unfractionated heparin.
• A very influential stimulus to nucleosynthesis research was an abundance table created by Hans Suess and Harold Urey that was based on the unfractionated abundances of the non-volatile elements found within unevolved meteorites.
• These assume slow net separation of continental crust from mantles that are still mostly unfractionated and are vigorously convecting in the same bottom-driven fashions, and yet produce different shallow and surface effects on each planet.
• LMWH shows increased inactivation of Factor Xa compared to unfractionated heparin, and fondaparinux, an agent based on the critical pentasacharide sequence of heparin, shows more selectivity than LMWH . This inactivation of Factor Xa by heparins is termed " indirect " since it relies on the presence of AT and not a direct interaction with Factor Xa.