vinblastine การใช้

• The drugs used were methotrexate, vinblastine, doxorubicin and cisplatin.
• These compounds include vinblastine, vincristine, vindesine, and vinorelbine.
• The original vinca alkaloids are completely natural chemicals that include vincristine and vinblastine.
• The discovery of vinblastine is generally considered a milestone in the development of chemotherapy.
• Catharanthine is one of the two precursors that form vinblastine, the other being vindoline.
• The upper skeletal modification of vinblastine gave vinorelbine which shows comparable activity as that of vinblastine.
• The upper skeletal modification of vinblastine gave vinorelbine which shows comparable activity as that of vinblastine.
• In the 1950s helped with the discovery of vincristine and vinblastine, widely used anti-cancer drugs.
• The plant produces about 130 of these compounds, including vinblastine and vincristine, two drugs used to treat cancer.
• Tabersonine is the first intermediate leading to the formation of vindoline one of the two precursors required for vinblastine biosynthesis.
• The inclusion of vinblastine allows for lower doses of bleomycin and reduced overall toxicity with larger resting periods between chemotherapy cycles.
• Fungi can synthesize other mitotic inhibitors including vinblastine, vincristine, podophyllotoxin, griseofulvin, aurantiamine, oxaline, and neoxaline.
• Western research yielded two anti-cancer drugs _ vinblastine and vincristine _ for treating childhood leukemia and Hodgkin's disease.
• Strictosidine is the base molecule for numerous pharmaceutically valuable metabolites including quinine, camptothecin, ajmalicine, serpentine, vinblastine and vincristine.
• "' Vinblastine "'is a highly potent drug which also has serious side effects especially on the neurological system.
• The drugs previously discovered in tropical forests include vincristine and vinblastine, which are used for cancer, and quinine, the oldest malaria medicine.
• In one such strategy, four drugs _ Adriamycin, Ketoconazole, Vinblastine, and Estramustine _ are administered during a two-month period.
• Vinglycinate a glycinate prodrug derived from the C-17-OH group of vinblastine showed similar antitumor activity and toxicity as that of vinblastine.
• Vinglycinate a glycinate prodrug derived from the C-17-OH group of vinblastine showed similar antitumor activity and toxicity as that of vinblastine.
• The drugs vinblastine and vincristine, used to treat Hodgkin's disease, leukemia and other cancers, were derived from the Madagascar periwinkle.