vlcad การใช้

• That's how Jamie Lazzaro learned VLCAD killed her baby.
• VLCAD is specific to very long-chain fatty acids, typically C16-acylCoA and longer.
• Consider the inherited metabolic diseases, which have such tongue-twisting names that many go by acronyms like VLCAD and MCAD.
• While DLG4 and VLCAD share common regulatory elements, they each have separate and distinct tissue-specific elements that confer their function.
• The VLCAD enzyme catalyzes most of fatty acid beta-oxidation by forming a C2-C3 trans-double bond in the fatty acid.
• With supplemental newborn screening, the same blood spot used for PKU testing can be used to test for up to 30 genetic metabolic diseases, such as MCAD and VLCAD.
• In mice that have VLCAD deficiency, there is little to no protein hyperacetylation in the liver; this implies that the VLCAD protein is also necessary for protein acetylation in this biological system.
• In mice that have VLCAD deficiency, there is little to no protein hyperacetylation in the liver; this implies that the VLCAD protein is also necessary for protein acetylation in this biological system.
• VLCAD has interesting gene structure in humans, in that is located in a head-to-head structure with the DLG4 gene on Chromosome 17, and that the transcribed regions of these genes overlap.
• Five of these nine classes are involved in fatty acid ?-oxidation ( SCAD, MCAD, LCAD, VLCAD, and VLCAD2 ), and the other four are involved in branched chain amino acid metabolism ( i3VD, i2VD, GD, and iBD ).