adrenodoxin การใช้

• Adrenodoxin reductase has been also called a ferredoxin-NADP + reductase.
• Adrenodoxin reductase is a mitochondrial flavoprotein as it carries a FAD type coenzyme.
• Adrenodoxin functions as a mobile shuttle that transfers electrons between ADXR and mitochondrial P450s.
• It also transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450.
• The FAD coenzyme receives two electrons from NADPH and transfers them one at a time to the electron transfer protein adrenodoxin.
• The mitochondrial P450 system electron transport chain including adrenodoxin reductase and adrenodoxin has been shown to leak electrons leading to the formation of superoxide radical.
• The mitochondrial P450 system electron transport chain including adrenodoxin reductase and adrenodoxin has been shown to leak electrons leading to the formation of superoxide radical.
• Adrenodoxin and adrenodoxin reductase are soluble peripheral membrane proteins located inside the mitochondrial matrix that appear to associate with each other primarily through electrostatic interactions.
• Adrenodoxin and adrenodoxin reductase are soluble peripheral membrane proteins located inside the mitochondrial matrix that appear to associate with each other primarily through electrostatic interactions.
• The initial source of the electrons is NADPH . The electrons are transferred from NADPH to P450scc via two electron transfer proteins : adrenodoxin reductase and adrenodoxin.
• The initial source of the electrons is NADPH . The electrons are transferred from NADPH to P450scc via two electron transfer proteins : adrenodoxin reductase and adrenodoxin.
• His lab was the first to clone the cDNAs and the gene coding for adrenodoxin reductase-the first enzyme in the electron transfer chain of the mitochondrial P450 system.
• Members of the 2Fe-2S ferredoxin family have a general core structure consisting of beta ( 2 )-alpha-beta ( 2 ), which includes putidaredoxin, terpredoxin, and adrenodoxin.
• During the bovine estrous cycle, plasma levels of progesterone increase in parallel to the levels of P450scc and its electron donor adrenodoxin, indicating that progesterone secretion is a result of enhanced expression of P450scc in the corpus luteum.
• By sequence and structural analyses of adrenodoxin reductase, Israel identified its binding sites for the electron donor and acceptor coenzymes, NADPH and FAD . Elucidation of the crystal structure of adrenodoxin reductase further verified Israel's identification of the coenzyme binding sites.
• By sequence and structural analyses of adrenodoxin reductase, Israel identified its binding sites for the electron donor and acceptor coenzymes, NADPH and FAD . Elucidation of the crystal structure of adrenodoxin reductase further verified Israel's identification of the coenzyme binding sites.
• The process of electron transfer from NADPH to P450scc is not tightly coupled; that is, during electron transfer from adrenodoxin reductase via adrenodoxin to P450scc, a certain portion of the electrons leak outside of the chain and react with O 2, generating superoxide radicals.
• The process of electron transfer from NADPH to P450scc is not tightly coupled; that is, during electron transfer from adrenodoxin reductase via adrenodoxin to P450scc, a certain portion of the electrons leak outside of the chain and react with O 2, generating superoxide radicals.