clofazimine การใช้

• Clofazimine is a phenazine dye and believed to work by interfering with DNA.
• Novartis was granted FDA approval of clofazimine in December 1986 as an orphan drug.
• Other medications for tuberculosis that can prolong the QT interval include fluoroquinolones and clofazimine.
• A three-drug combination of dapsone, rifampicin and clofazimine can cure the disease.
• Today, the drugs of choice for treating leprosy are dapsone, rifampicin and clofazimine.
• While in Nigeria, he pioneered the use of anti-leprosy drug, clofazimine.
• Clofazimine, an antileprosy drug, may be given as an alternative treatment in patients resistant to corticosteroids.
• A multidrug therapy _ consisting of three drugs ( dapsone, rifampicin and clofazimine ) _ kills the pathogen.
• The search for additional anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s.
• Currently, a multidrug treatment ( MDT ) is recommended by the World Health Organization, including dapsone, rifampicin and clofazimine.
• The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s.
• Two other drugs, clofazimine and rifampin, became available in the 1970s and are now employed with dapsone in multi-drug therapy.
• "' Myoconda "', the company's lead product, is a combination of the antibiotics rifabutin, clarithromycin and clofazimine.
• With multidrug therapy used as the standard treatment of Hansen's disease, rifampicin is always used in combination with dapsone and clofazimine to avoid causing drug resistance.
• Lucio's phenomenon is treated by anti-leprosy therapy ( dapsone, rifampin, and clofazimine ), optimal wound care, and treatment for bacteremia including antibiotics.
• The World Health Organization said experts who met from May 26 until Tuesday in Geneva reviewed the success of the treatment with three powerful drugs _ dapsone, rifamipicin and clofazimine.
• In 2010, the World Health Organisation ( WHO ) stated that it did not recommend thalidomide due the difficulty of adequately controlling its use, and due to the availability of clofazimine.
• Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum ( ENL ) . ( From AMA Drug Evaluations Annual, 1993, p1619 ).
• K v 1.3 is blocked margatoxin, kaliotoxin, charybdotoxin, noxiustoxin, anuroctoxin ) and sea anemone ( anti-mycobacterial activity, but could well have been an immunomodulatory effect by clofazimine.
• "' 1980 "' Vincent Barry and his team win the 1980 UNESCO Science Prize for their discovery of anti-leprosy drug clofazimine, developed with the assistance of The Leprosy Mission.