clofibrate การใช้

• "' Acefylline clofibrol "'is a derivative of acefylline and clofibrate used as an hypolipidemic agent.
• In trophoblast-derived cell lines, up-regulated VLDLR expression occurs when cells are incubated with hypolipidemic agents such as insulin and clofibrate.
• Cholesterol is the main constituent of atheroma, the fatty lumps in the wall of dietary measures, such as a low-fat diet, and poorly tolerated medicines, such as clofibrate, cholestyramine, and nicotinic acid.
• They also serve as carriers for molecules of low water solubility this way isolating their hydrophobic nature, including lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids ( apoprotein ), calcium, ions ( transferrin ), and some drugs like warfarin, phenobutazone, clofibrate & phenytoin.
• The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering ( 47 % more deaths during treatment with clofibrate and 5 % after treatment with clofibrate ) than the non-treated high cholesterol group.
• The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering ( 47 % more deaths during treatment with clofibrate and 5 % after treatment with clofibrate ) than the non-treated high cholesterol group.
• The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering ( 47 % more deaths during treatment with clofibrate and 5 % after treatment with clofibrate ) than the non-treated high cholesterol group.
• The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed excess mortality in the clofibrate-treated group despite successful cholesterol lowering ( 47 % more deaths during treatment with clofibrate and 5 % after treatment with clofibrate ) than the non-treated high cholesterol group.
• On the positive side, clinical trials established the effectiveness of vaccines against polio, measles and rubella, the ability of aspirin to reduce the risk of stroke, the role of cholesterol-lowering clofibrate in preventing deaths from heart attacks and the usefulness of the drug AZT in delaying the onset of AIDS in otherwise healthy people with H . I . V ., the virus that causes the disease.