diosmin การใช้

• Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats.
• Synthetic flavones include diosmin, flavoxate, and 7, 8-dihydroxyflavone.
• Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.
• There are extensive clinical trials that show diosmin improves all stages of venous disease including venous ulcers and improves quality of life.
• Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.
• Diosmin reduces the expression of endothelial adhesion molecules ( ICAM1, VCAM1 ), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.
• Diosmin is currently a prescription medication in some European countries ( under the Dio-PP, Venotec, Daflon etc . tradenames ), and is sold as a nutritional supplement in the United States.
• It is also speculated that diosmin might have potential in the treatment of neurodegenerative disease s, such as Alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.
• Coumarin and other "'benzopyrone "'s, such as 5, 6 benzopyrone, 1, 2 benzopyrone, diosmin and others are known to stimulate macrophages to degrade extracellular albumin, allowing faster resorption of edematous fluids.
• The flavones diosmin, cirsimaritin, salvigenin, cirsilineol, cirsiliol, luteolin, apigenin and the flavanone naringenin, as well as the flavone glycosides luteolin-7-O-?-D-glucoside and apigenin-7-O-?-D-glucoside, and the diglycosides luteolin-7-O-?-D-rutinoside, luteolin-7-O-?-D-neohesperidoside ( veronicastroside ) and luteolin-7-O-?-D-sambubioside can be found in " T . gnaphalodes ".