exonuclease การใช้

• The FAN1 protein possesses endonuclease and exonuclease functions to remove ICLs.
• An exonuclease trails the complex and digests the ss-DNA tail.
• Exo is a double stranded DNA exonuclease with 5 to 3 activity.
• XRN1 is an exonuclease that degrades the ITS2 region during processing of RN45s.
• The next proposed step is to bind an exonuclease onto the ?HL pore.
• In high concentrations FAN1 has been shown to exhibit 3 5 exonuclease activity.
• Pol ? has limited processivity and lacks 32 exonuclease activity for proofreading errors.
• S478N, in the exonuclease domain, has been validated as damaging and pathogenic.
• GAM is an inhibitor of RecBCD, an exonuclease found in E . coli.
• This enzyme has an associated 3 ?! 5 exonuclease activity along with primase activity.
• Notably, theorists have shown that sequencing via exonuclease enzymes as described here is not feasible.
• Yeast contains Rat1 and Xrn1 exonuclease.
• By itself, the protein has 3'to 5'exonuclease activity and endonuclease activity.
• Pol ? lacks 3'to 5'exonuclease activity and is a moderate fidelity polymerase.
• Most contaminating DNA is degraded by the addition of a second single-strand specific exonuclease.
• This process involves the exonuclease's catching up to the pol II and terminating the transcription.
• The ? subunit possesses DNA polymerase activity and the ? subunit is a 3-5 exonuclease.
• This delay gives time for the DNA to be switched from the polymerase site to the exonuclease site.
• The exonuclease activity of Rat1 degrades the RNA strand and halts transcriptions upon catching up to the polymerase.
• The mutations that have been observed are in the regions that affect the exonuclease domain and polymerase domains.