fetuins การใช้

• Fetuins exist in all vertebrate genomes including fish and reptiles.
• Fetuins thus belong to the cystatin superfamily of proteins.
• Fetuins are carrier proteins like albumin.
• Fetuins like histidine-rich glycoprotein and kininogens are secreted ( so-called type 3 ) cystatins.
• Fetuins are members of a family of proteins that evolved from the protein cystatin by gene duplication and exchange of gene segments.
• Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation.