folliculin การใช้

• The function of the folliculin protein has yet to be determined but current research suggests it may act as a tumor suppressor.
• The C-terminal end of folliculin has shown to be the domain through which it interacts with FNIP1, and thereby possibly the mTOR pathway.
• The lysine at this position is found to be conserved between invertebrate and vertebrate orthologs of folliculin, indicating that it is important to the protein's function.
• Any of these conditions that occurs in a family can indicate a diagnosis of Birt Hogg Dub?syndrome, though it is only confirmed by a genetic test for a mutation in the FLCN gene, which codes for the protein folliculin.