follistatin การใช้

• Follistatin is involved in the development of the embryo.
• We also found Myod1 and follistatin to be increased in response to decorin overexpression.
• Follistatin inhibits Activin, which it binds.
• Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
• Follistatin and BMPs are also known to play a role in folliculogenesis within the ovary.
• This gene encodes a protein with similarity to follistatin, an BMP-4-binding protein.
• The activin-binding protein follistatin is produced by folliculostellate ( FS ) cells of the anterior pituitary.
• It is achieved by using transgenes expressing follistatin, which inhibits myostatin, and the development of two muscle layers.
• In the reproductive system, inhibins and follistatin counterregulate activins, to control follicle-stimulating hormone and so the release of gonads.
• In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion.
• The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain.
• Animals lacking myostatin or animals treated with substances such as follistatin that block the binding of myostatin to its receptor have significantly larger muscles.
• Both of these roles are vital in tissue rebuilding and repair, and may account for follistatin's high presence in the skin.
• Follistatin, which is also produced in all body tissue, inhibits activin and gives the rest of the body more control over the axis.
• Other genes which can inhibit or interact with BMP4 are noggin, follistatin, gremlin, which is all expressed in the developing hair follicles.
• Follistatin also is implicated in prostate cancers where mutations in its gene may preventing it from acting on activin which has anti-proliferative properties.
• Studies of gene expression show that a specific complement of genes, such as follistatin and multiple cyclin kinase inhibitors are involved in ovarian development.
• In progenitor cells of the exocrine pancreas, important molecules that induce differentiation include follistatin, fibroblast growth factors, and activation of the Notch receptor system.
• In the tissues activin has a strong role in cellular proliferation, thereby making follistatin the safeguard against uncontrolled cellular proliferation and also allowing it to function as an instrument of cellular differentiation.
• In the fruit fly " Drosophila melanogaster ", as well as in other protostomes, the ?-type transforming growth factor ( Noggin, Follistatin ) are expressed dorsally.